Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of angiotensin converting enzyme gene polymorphism on patients with in-stent restenosis after percutaneous coronary intervention

Tarek A Abdelaziz¹ , Randa H Mohamed², Gehan F Balata³, Omar Y El-Azzazy⁴

¹Department of Cardiology; ²Department of Medical Biochemistry, Faculty of Medicine; ³Department of Pharmaceutics; ⁴Department of Pharmacy Practice, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

For correspondence:- Tarek Abdelaziz Email: oyhaz631@gmail.com Tel:+201092392870

Accepted: 22 January 2021 Published: 28 February 2021

Citation: Abdelaziz TA, Mohamed RH, Balata GF, El-Azzazy OY. Effect of angiotensin converting enzyme gene polymorphism on patients with in-stent restenosis after percutaneous coronary intervention. Trop J Pharm Res 2021; 20(2):403-409 doi: 10.4314/tjpr.v20i2.26

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the association between common single nucleotide polymorphisms (SNPs) in angiotensin converting enzyme (ACE) gene and the risk of in-stent restenosis (ISR) and/or the response to angiotensin converting enzyme inhibitor ACEI in individuals with stable coronary artery disease (CAD) after stent implantation.

Methods: The total population of this study consisted of 200 Egyptian individuals divided into 2 groups - in-stent restenosis (ISR) and non ISR group). Genomic DNA was withdrawn from EDTA whole blood applying a spin column approach and ACE gene insertion/deletion (I/D) polymorphisms were determined by polymerase chain reaction (PCR).

Results: Carriers of allele D of ACE gene were significantly more liable to ISR occurrence. However, carriers of allele I were significantly more liable to ISR occurrence after administration of ACEI. There is a negative interaction between DD genotype of ACE gene and ACEI administration on ISR after percutaneous coronary intervention (PCI). However, there is a positive interaction between II and ID genotype of ACE gene and ACEI administration on ISR after PCI with bare metal stents (BMS).

Conclusion: It is beneficial to implement ACEI in therapeutic regimen in individuals with ID or II genotypes of ACE gene, especially with BMS implementation.

Keywords: ACE gene, In-stent restenosis, Polymorphism, Coronary artery disease